Safety of Annona muricata Extract Supplementation for Colorectal Cancer Patients
Item
Title
Safety of Annona muricata Extract Supplementation for
Colorectal Cancer Patients
Colorectal Cancer Patients
list of authors
1. Lili Indrawati
2. Purwantyastuti
3. Murdani Abdullah
4. Ingrid S Surono
5. Ibrahim Basir
2. Purwantyastuti
3. Murdani Abdullah
4. Ingrid S Surono
5. Ibrahim Basir
Abstract
ABSTRACT
Background: People have used Annona muricata (A. muricata) leaves traditionally as tea drinks. Traditional
use of A. muricata leaves is as an infusion which is closed to water extract. The potential health benefit of A.
muricata tea leaves that is traditionally used for maintaining health which lately is being used by cancer patients.
Therefore it is urgent to verify the safety of A. muricata leaves extract.
Method: A randomized double blind placebo controlled trial was conducted on 30 colorectal cancer out
patients who had undergone primary tumor resection. Twenty eight subjects completed the study, divided into
two groups, namely ethanol-soluble fraction of A. muricata leaves water extract (ESFAM) (n = 14), and placebo
(n = 14) for 8 weeks. Peripheral blood samples were withdrawn from subjects by venipuncture at baseline and
at the end of the study period.
Results: The effect on bone marrow can be considered to be safe. The measure in indices of organs function,
i.e liver and kidney also showed similar results and within normal range after supplementation. The dose given
to the subjects is safe and highly tolerable, as shown by very few (6.7%) of patients complained intolerable
adverse effects.
Conclusion: This study indicates the safety of ESFAM supplementation.
Keywords: colorectal cancer, Annona muricata leaves, adverse effect, vital organs
ABSTRAK
Latar Belakang: Daun Annona muricata (A. muricata/sirsak) telah digunakan secara tradisional sebagai
minuman teh. Penggunaan rebusan daun A. muricata merupakan sediaan yang mirip dengan ekstrak air.
Potensi manfaat kesehatan teh daun A. muricata yang secara tradisional digunakan untuk menjaga kesehatan
akhir-akhir ini juga dimanfaatkan oleh pasien kanker. Oleh karena itu sangat mendesak untuk memverifikasi
keamanan ekstrak daun A. muricata.
Metode: Uji klinik acak terkontrol (doble blind RCT) dilakukan pada 30 pasien kanker kolorektal yang telah
menjalani reseksi tumor primer. Dua puluh delapan subjek menyelesaikan penelitian selama 8 minggu, dibagi menjadi dua kelompok, yaitu kelompok ethanol-soluble fraction of A. muricata leaves water extract (ESFAM)
(n = 14), dan plasebo (n = 14). Sampel darah perifer diperiksa pada awal dan pada akhir masa studi.
Hasil: Efek pada sumsum tulang dapat dianggap aman. Fungsi hati dan ginjal juga menunjukkan hasil yang
sama dan dalam rentang normal setelah suplementasi. Dosis yang diberikan kepada subjek aman dan sangat
ditoleransi, hanya sedikit (6,7%) dari pasien mengeluh efek samping.
Simpulan: Penelitian ini menunjukkan keamanan suplementasi ESFAM.
Kata kunci: kanker kolorektal, daun Annona muricata, efek samping, organ vital
Background: People have used Annona muricata (A. muricata) leaves traditionally as tea drinks. Traditional
use of A. muricata leaves is as an infusion which is closed to water extract. The potential health benefit of A.
muricata tea leaves that is traditionally used for maintaining health which lately is being used by cancer patients.
Therefore it is urgent to verify the safety of A. muricata leaves extract.
Method: A randomized double blind placebo controlled trial was conducted on 30 colorectal cancer out
patients who had undergone primary tumor resection. Twenty eight subjects completed the study, divided into
two groups, namely ethanol-soluble fraction of A. muricata leaves water extract (ESFAM) (n = 14), and placebo
(n = 14) for 8 weeks. Peripheral blood samples were withdrawn from subjects by venipuncture at baseline and
at the end of the study period.
Results: The effect on bone marrow can be considered to be safe. The measure in indices of organs function,
i.e liver and kidney also showed similar results and within normal range after supplementation. The dose given
to the subjects is safe and highly tolerable, as shown by very few (6.7%) of patients complained intolerable
adverse effects.
Conclusion: This study indicates the safety of ESFAM supplementation.
Keywords: colorectal cancer, Annona muricata leaves, adverse effect, vital organs
ABSTRAK
Latar Belakang: Daun Annona muricata (A. muricata/sirsak) telah digunakan secara tradisional sebagai
minuman teh. Penggunaan rebusan daun A. muricata merupakan sediaan yang mirip dengan ekstrak air.
Potensi manfaat kesehatan teh daun A. muricata yang secara tradisional digunakan untuk menjaga kesehatan
akhir-akhir ini juga dimanfaatkan oleh pasien kanker. Oleh karena itu sangat mendesak untuk memverifikasi
keamanan ekstrak daun A. muricata.
Metode: Uji klinik acak terkontrol (doble blind RCT) dilakukan pada 30 pasien kanker kolorektal yang telah
menjalani reseksi tumor primer. Dua puluh delapan subjek menyelesaikan penelitian selama 8 minggu, dibagi menjadi dua kelompok, yaitu kelompok ethanol-soluble fraction of A. muricata leaves water extract (ESFAM)
(n = 14), dan plasebo (n = 14). Sampel darah perifer diperiksa pada awal dan pada akhir masa studi.
Hasil: Efek pada sumsum tulang dapat dianggap aman. Fungsi hati dan ginjal juga menunjukkan hasil yang
sama dan dalam rentang normal setelah suplementasi. Dosis yang diberikan kepada subjek aman dan sangat
ditoleransi, hanya sedikit (6,7%) dari pasien mengeluh efek samping.
Simpulan: Penelitian ini menunjukkan keamanan suplementasi ESFAM.
Kata kunci: kanker kolorektal, daun Annona muricata, efek samping, organ vital